Research Articles
Crystallization Optimization for Lower PMI: Strategies for Sustainable Pharmaceutical Manufacturing
This article provides a comprehensive guide for researchers and drug development professionals on optimizing crystallization processes to significantly lower Process Mass Intensity (PMI).
Navigating HPAPI Challenges: A 2025 Guide to Potency, Safety, and Compliance
This article provides a comprehensive guide for researchers, scientists, and drug development professionals tackling the unique challenges of Highly Potent Active Pharmaceutical Ingredients (HPAPIs).
In-Line Monitoring for Enhanced Process Control and Quality in Biopharmaceutical Manufacturing
This article explores the critical role of in-line monitoring and Process Analytical Technology (PAT) in advancing biopharmaceutical manufacturing.
Optimizing Solvent Selection for Lower PMI: A Strategic Guide for Sustainable Drug Development
This guide provides drug development researchers and scientists with a comprehensive framework for selecting solvents to minimize Process Mass Intensity (PMI), a key green chemistry metric.
Process Mass Intensity (PMI) in Green Chemistry: A Strategic Guide for Sustainable Drug Development
This article provides a comprehensive overview of Process Mass Intensity (PMI), a pivotal green chemistry metric for researchers and drug development professionals.
Optimizing Drug Development: A Project Manager's Guide to Design of Experiments (DoE)
This article provides a comprehensive framework for applying Design of Experiments (DoE) in pharmaceutical development and manufacturing.
Quality by Design for Pharmaceutical Manufacturing: A Strategic Framework to Reduce Process-Related Issues and Enhance Product Quality
This article provides a comprehensive guide to the implementation of Quality by Design (QbD) principles in pharmaceutical development and manufacturing.
Strategies for Solvent Reduction: Using PMI Metrics to Develop Greener Pharmaceutical Processes
This article provides a comprehensive guide for researchers and drug development professionals on leveraging the Process Mass Intensity (PMI) metric to drive significant solvent reduction in pharmaceutical manufacturing.
PMI Benchmarking: How the ACS GCI Pharmaceutical Roundtable Drives Sustainable Drug Development
This article explores the pivotal role of the ACS Green Chemistry Institute (GCI) Pharmaceutical Roundtable in establishing Process Mass Intensity (PMI) as the key metric for benchmarking and advancing sustainability...
Sustainable API Synthesis: Green Chemistry, Biocatalysis, and Continuous Manufacturing for 2025
This article provides a comprehensive analysis of sustainable manufacturing practices in Active Pharmaceutical Ingredient (API) synthesis, tailored for researchers, scientists, and drug development professionals.