Research Articles
Green Chemistry in Drug Development: Applying the 12 Principles for Sustainable Innovation
This article provides a comprehensive guide to the theory and practice of the 12 Principles of Green Chemistry for researchers, scientists, and professionals in drug development.
A Practical Guide to LSER Model Calibration and Benchmarking for Robust Drug Property Prediction
This article provides a comprehensive guide to the calibration and benchmarking of Linear Solvation Energy Relationship (LSER) models, a critical tool for predicting drug properties in pharmaceutical research. Tailored for drug development professionals, it covers foundational principles, step-by-step calibration methodologies, advanced troubleshooting for model optimization, and rigorous validation techniques. By synthesizing current scientific literature, the content delivers actionable strategies to build, refine, and confidently deploy reliable LSER models for applications ranging from solubility prediction to partition coefficient estimation, ultimately supporting more efficient and informed decision-making in drug discovery.
Analytical Eco-Scale vs. AGREE: A Strategic Guide to Green Method Assessment for Pharmaceutical Scientists
This article provides a comprehensive comparison of two pivotal green analytical chemistry (GAC) tools—the Analytical Eco-Scale and the AGREE metric—tailored for researchers and professionals in drug development. It explores the foundational principles, scoring methodologies, and visual outputs of each system, guiding the selection of the most appropriate tool for specific pharmaceutical applications. Through practical case studies, such as the determination of atorvastatin, and integration with broader frameworks like White Analytical Chemistry (WAC), we demonstrate how to troubleshoot limitations, optimize assessments, and validate method sustainability. This guide empowers scientists to make informed decisions, ensuring their analytical methods are not only scientifically robust but also environmentally responsible.
Beyond the Hype: A Practical Guide to Green Solvent Replacement for Pharmaceutical Researchers
This article provides a comprehensive framework for researchers and drug development professionals navigating the complex transition from conventional to green solvents. It covers the foundational rationale for solvent replacement, explores emerging bio-based and neoteric solvents, and details systematic methodologies for selection and integration. The content addresses key challenges in performance, scalability, and economic viability, supported by case studies from the pharmaceutical industry and validated by comparative data and emerging computational tools, offering a roadmap for achieving both sustainability and efficacy in pharmaceutical processes.
Science and Food Fictions: Agricultural Technologies and the Modern Diet
Explore how agricultural technologies transformed our food system, their environmental impacts, and the path toward sustainable food production.
The Invisible Scientist: How AI is Revolutionizing Chemical Biology
Explore how artificial intelligence is transforming chemical biology, from protein structure prediction to self-driving laboratories and AI-designed molecules.
Engineering Next-Generation Hybrid Nanomaterials: From Advanced Sensors to Sustainable Catalytic Processes
Explore the revolutionary world of hybrid nanomaterials and their applications in advanced sensors and sustainable catalytic processes for clean energy production.
Organic Farming: Cultivating a Healthier Future for Food and Environment
Explore the benefits of organic farming for food quality and environmental health. Learn about reduced pesticide exposure, nutritional advantages, and sustainable agricultural practices.
MXenes: The Two-Dimensional Wonder Material Powering Our Sustainable Future
Discover how MXenes, revolutionary two-dimensional materials, are transforming sustainable energy solutions through advanced energy storage, environmental sensing, and catalysis.
The East-West Divide: How Technology is Reshaping China's Green Farming Revolution
Exploring regional disparities in technology-driven green agricultural development across China and the spatial spillover effects influencing this transformation.